Postnatal dexamethasone-induced programmed hypertension is related to the regulation of melatonin and its receptors
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- 作者：Hsin-Yu Changa ; You-Lin Tainb ; tainyl@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：DEX ; dexamethasone ; HDAC ; histone deacetylase ; MEL ; melatonin ; MT1 ; melatonin receptor-1 ; MT2 ; melatonin receptor-2 ; RORα ; retinoid acid receptor-α ; RZRβ ; retinoid Z receptor-β
- 刊名：Steroids
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：108
- 期：Complete
- 页码：1-6
- 全文大小：713 K
文摘
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Postnatal dexamethasone (DEX) induced programmed hypertension in later life.
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Maternal melatonin therapy prevented DEX-induced programmed hypertension.
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Postnatal DEX decreased renal MT2 protein level, which melatonin prevented.
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Melatonin therapy increased levels of RORα protein and melatonin in the kidney.
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Postnatal DEX-induced programmed hypertension is related to melatonin receptors.