Regulation of SIRT1 in aging: Roles in mitochondrial function and biogenesis
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- 作者：Yujia Yuana ; Vinicius Fernandes Cruzatb ; c ; Philip Newsholmeb ; Jingqiu Chenga ; Younan Chena ; b ; chenyounan@scu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Yanrong Lua ; luyanrong@scu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：SIRT1 ; sirtuin 1 ; PGC-1α ; peroxisome proliferator activated receptor γ co-activator 1α ; HIF-1α ; hypoxia-inducible factor 1α ; ROS ; reactive oxygen species ; RC ; respiratory chain ; NAD ; nicotinamide adenine dinucleotide ; mtDNA ; mitochondrial DNA ; OXPHOS ; oxidative phosphorylation ; TFAM ; mitochondrial transcription factor A ; TFB ; mitochondrial transcription factor B ; NRF ; nuclear respiratory factors ; ERRα ; estrogen related receptor α ; CREB ; cAMP response element ; YY1 ; ying yang 1 transcription facto
- 刊名：Mechanisms of Ageing and Development
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：155
- 期：Complete
- 页码：10-21
- 全文大小：2178 K
文摘
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Descripting the dysregulation of mitochondrial biogenesis in the development of aging and aging-related diseases.
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Completed description of the transcriptional and post-translational regulation of SIRT1 in aging process.
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Regulation of mitochondrial biogenesis via SIRT1-PGC1α dependent and independent pathway have been elaborated in this paper.