Upregulation of microRNA-22 contributes to myocardial ischemia-reperfusion injury by interfering with the mitochondrial function
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- 作者：Jian-Kui Dua ; Bin-Hai Conga ; Qing Yua ; He Wanga ; Long Wanga ; Chang-Nan Wanga ; Xiao-Lu Tanga ; Jian-Qiang Lub ; Xiao-Yan Zhua ; xiaoyanzhu@smmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Xin Nia ; nixin@smmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：MicroRNA-22 ; Cardiomyocyte ; Mitochondria ; Ischemia-reperfusion ; Sirt1 ; PGC1α ; p53
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：96
- 期：Complete
- 页码：406-417
- 全文大小：3647 K
文摘
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Upregulation of miR-22 contributes to myocardial I/R injury.
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MiR-22 causes mitochondrial dysfunction and cell injury by targeting Sirt1/ PGC1α.
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H/R-induced upregulation of miR-22 may be due to ROS-induced activation of p53.
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The therapeutic potential of miR-22 inhibition for acute myocardial I/R injury.