Aqueous extract of Glycyrrhiza inflata inhibits aggregation by upregulating PPARGC1A and NFE2L2-ARE pathways in cell models of spinocerebellar ataxia 3
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- 作者：Chiung-Mei Chena ; Yu-Ting Wenga ; 1 ; Wan-Ling Chena ; 1 ; Te-Hsien Linb ; 1 ; Chih-Ying Chaoa ; Chih-Hsin Lina ; I-Cheng Chena ; Li-Ching Leeb ; Hsuan-Yuan Linc ; Yih-Ru Wua ; Yi-Chun Chena ; Kuo-Hsuan Changa ; Hsiang-Yu Tangd ; Mei-Ling Chengd ; Guey-Jen Lee-Chenb ; t43019@ntnu.edu.tw" class="auth_mail ; Jung-Yaw Linb ; c ; jylin@ntnu.edu.tw" class="auth_mail
- 关键词：Spinocerebellar ataxia ; ATXN3 ; Glycyrrhiza inflata ; Licochalcone A ; Ammonium glycyrrhizinate ; PPARGC1A ; NFE2L2 ; Mitochondrial biogenesis ; Oxidative stress ; Free radicals
- 刊名：Free Radical Biology and Medicine
- 出版年：June 2014
- 年：2014
- 卷：71
- 期：Complete
- 页码：339-350
- 全文大小：3326 K
文摘
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We report antiaggregation potential of G. inflata and components in 293/SH-SY5Y SCA3 cells.
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G. inflata and components upregulate PPARGC1A, a regulator of mitochondrial biogenesis.
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G. inflata and components activate NFE2L2–ARE signaling and suppress GSSG and ROS.