From genotype to phenotype: Are there imaging characteristics associated with lung adenocarcinomas harboring RET and ROS1 rearrangements?
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- 作者：Andrew J. Plodkowskia ; plodkowa@mskcc.org" class="auth_mail" title="E-mail the corresponding author ; Alexander Drilonb ; DrilonA@mskcc.org" class="auth_mail" title="E-mail the corresponding author ; Darragh F. Halpennya ; halpennd@mskcc.org" class="auth_mail" title="E-mail the corresponding author ; Dearbhail O&rsquo ; Driscolla ; dearbhailodriscoll@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Donald Blaira ; djblair73@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Anya M. Litvakb ; alitvak@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Junting Zhengc ; ZhengJ@mskcc.org" class="auth_mail" title="E-mail the corresponding author ; Chaya S. Moskowitzc ; moskowc1@mskcc.org" class="auth_mail" title="E-mail the corresponding author ; Michelle S. Ginsberga ; ginsberm@mskcc.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Lung adenocarcinoma ; Computed tomography ; ROS1 rearrangement ; RET rearrangement ; EGFR mutation
- 刊名：Lung Cancer
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：90
- 期：2
- 页码：321-325
- 全文大小：679 K
文摘
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Radiogenomics can try to characterize the appearance of different lung cancers.
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Lung adenocarcinomas with RET and ROS1 fusions share many radiographic features.
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ROS1 tumors present as more peripheral lesions.
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Genetic testing in lung adenocarcinoma can offer additional targeted treatment.