Anti-ulcer activity of Cyrtocarpa procera analogous to that of Amphipterygium adstringens, both assayed on the experimental gastric injury in rats

详细信息    查看全文

• 作者：Hortensia Rosas-Acevedo^a ; ^e ; Teresa Terrazas^b ; Ma. Eva Gonz&#xe1 ; lez-Trujano^c ; ^d ; ^{evag@imp.edu.mx} ; Yolanda Guzm&#xe1 ; n^d ; Marcos Soto-Hern&#xe1 ; ndez^e
• 关键词：Anatomy ; Amphipterygium adstringens ; Bark ; Cyrtocarpa procera ; Ethanol ; Gastric ulcer ; Periderm
• 刊名：Journal of Ethnopharmacology
• 出版年：2011
• 出版时间：8 March 2011
• 年：2011
• 卷：134
• 期：1
• 页码：67-73
• 全文大小：1167 K

文摘

Ethnopharmacological relevance

The bark of Amphipterygium adstringens (Aa) is commonly mixed or adulterated with the bark of Cyrtocarpa procera (Cp) and sold in Mexican markets. Aa is a well known species in Mexico used as decoction to relieve ulcers. Scientific reports reinforcing the anti-ulcer activity of Aa have been previously described, but those describing the anti-ulcer properties of Cp as a substitute for Aa in folk medicine are scarce.

Aim of the study

To investigate anatomical and phytochemical differences between these species, as well as to assess the anti-ulcer effect of Cp extracts in comparison to the Aa extracts.

Material and methods

Anatomical micro-technique and physical and spectroscopic data were used to analyze differences between Cp and Aa. Regard to the pharmacological activity, it was assessed by using the ethanol-induced gastric damage model in rats.

Results

Whereas the bark anatomy of Aa was characterized by vertical canals in the periderm and the rare occurrence of fibers in its phloem, a periderm without vertical canals and abundant fibers in the phloem were distinctive features of Cp. Phytochemical analysis allowed the identification of tirucallane, masticadienonic and 3α-hydroxymasticadienonic acids as major components in Aa, while β-amyrin and β-sitosterol were obtained from Cp. Gastric lesions observed in the control group decreased in the presence of 100 mg/kg of hexane, ethyl acetate and methanol extracts from the normal or regenerated bark of Cp, thus resembling the anti-ulcer effect of Aa. Nevertheless, major anti-ulcer potency was observed with the most active methanol extract from Cp obtained from normal [the effective dose fifty ED₅₀ = 45.54 mg/kg] or regenerated (ED₅₀ = 36.68 mg/kg) bark in comparison to Aa (ED₅₀ = 115.64 mg/kg).

Conclusion

Chemical and anatomical differences were found between these species, but since the anti-ulcer activity of Cp is similar to that shown by Aa our results reinforce the use of both species for the relief of gastric ulcer in folk medicine.