ent-Rosane and abietane diterpenoids as cancer chemopreventive agents

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• 作者：Marvin J. Nú ; ñ ; ez^a ; ^b ; Carolina P. Reyes^a ; Ignacio A. Jim&#xe9 ; nez^a ; Hirotaka Hayashi^c ; Harukuni Tokuda^c ; Isabel L. Bazzocchi^a ; ^{ilopez@ull.es}
• 关键词：Maytenus cuzcoina ; Crossopetalum uragoga ; ent-Rosane ; Abietane ; Epstein-Barr virus ; Two-stage carcinogenesis ; Chemopreventive agents
• 刊名：Phytochemistry
• 出版年：2011
• 出版时间：April 2011
• 年：2011
• 卷：72
• 期：4-5
• 页码：385-390
• 全文大小：363 K

文摘

Two ent-rosane- (cuzcol, 1 and 6-dehydroxycuzcol, 2) and a abietatriene- (salvadoriol, 3) type diterpenoids have been isolated from Maytenus cuzcoina and Crossopetalum uragoga, respectively, along with five known diterpene compounds (4–8). Their stereostructures have been elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR techniques, and computational data. The absolute configuration of cuzcol was determined by application of Riguera ester procedure. This is the first instance of isolation of ent-rosane diterpenoids from species of the Celastraceae. The isolated diterpenes were found to be potent anti-tumour-promoter agents, and carnosol (7) also showed a remarkable chemopreventive effect in an in vivo two-stage carcinogenesis model.