The role of altered cutaneous immune responses in the induction and persistence of rosacea
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- 作者：Anatte Margalit
- 关键词：AMPs ; antimicrobial peptides ; ETR ; erythematotelangiectatic rosacea ; hTCEpi ; telomerase-immortalized human corneal epithelial cell line ; MC ; mast cells ; KLK5 ; kallikrein 5 ; PPR ; papulopustular rosacea ; PRR ; pattern recognition receptors ; TLR ; toll-like receptor ; PAMPs ; pathogen-associated molecular patterns ; DAMPs ; danger-associated molecular patterns
- 刊名：Journal of Dermatological Science
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：82
- 期：1
- 页码：3-8
- 全文大小：1035 K
文摘
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- <p id="par0005">Rosacea is a chronic inflammatory skin disease that may arise from alterations in the cutaneous immune response.p>
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- <p id="par0010">Rosacea patients demonstrate alterations in the cutaneous immune response including elevated levels of LL-37, increased expression of TLR-2 and increased amounts of vitamin D3 in the epidermis.p>
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- <p id="par0015">Rosacea patients demonstrate elevated numbers of Demodex mites and these may directly stimulate an immune response or transport bacteria that initiate an inflammatory immune response.p>
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- <p id="par0020">Rosacea can be treated by the use of antibiotics which may target bacteria populations in the skin and/or reduce inflammation.p>
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- <p id="par0025">Recent therapies have sought to eliminate Demodex mites from the skin and show some promise in controlling this disfiguring condition.p>