Pre-Anchoring of Pin1 to Unphosphorylated c-Myc in a Fuzzy Complex Regulates c-Myc Activity
详细信息 查看全文
- 作者：Sara Helander1 ; 5 ; 7 ; Meri Montecchio1 ; 5 ; Robert Pilstå ; l2 ; 5 ; Yulong Su3 ; 5 ; Jacob Kuruvilla4 ; Malin Elvé ; n1 ; 6 ; Javed M.E. Ziauddin1 ; Madhanagopal Anandapadamanaban1 ; Susana Cristobal4 ; Patrik Lundströ ; m1 ; Rosalie C. Sears3 ; Bjö ; rn Wallner2 ; Maria Sunnerhagen1 ; maria.sunnerhagen@liu.se" class="auth_mail" title="E-mail the corresponding author
- 刊名：Structure
- 出版年：2015
- 出版时间：1 December 2015
- 年：2015
- 卷：23
- 期：12
- 页码：2267-2279
- 全文大小：3971 K
文摘
- •
Pin1 binds unphosphorylated Myc distant from the isomerization target site
- •
Binding site mutations trap Myc in a stable, transcriptionally less active state
- •
A Myc-Pin1 “fuzzy complex” is described by NMR and molecular simulations
- •
The first structure of Pin1 in complex with a long, disordered target peptide