Growth factors and pathogenesis
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- 作者：Md Soriful Islam ; PhDa ; b ; Stefania Greco ; Msca ; Milijana Janjusevic ; Msca ; Andrea Ciavattini ; MDc ; Stefano Raffaele Giannubilo ; MDc ; Assunta D'Adderio ; Msca ; Alessandra Biagini ; MDc ; Rosamaria Fiorini ; PhDd ; Mario Castellucci ; MD ; PhDa ; m.castellucci@univpm.it" class="auth_mail" title="E-mail the corresponding author ; Pasquapina Ciarmela ; PhDa ; e ; p.ciarmela@univpm.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：uterine leiomyoma ; uterine fibroid ; growth factors ; activin-A ; TGF-β ; VEGF
- 刊名：Best Practice & Research Clinical Obstetrics & Gynaecology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：34
- 期：Complete
- 页码：25-36
- 全文大小：703 K
文摘
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Leiomyoma cell growth is dependent on ovarian hormone activity through growth factors.
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Growth factors exert their effects activating multiple signal transduction pathways.
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Growth factor signaling pathways include Smad 2/3, ERK 1/2, PI3K, and β-catenin.
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Therapeutic compounds downregulate growth factors and their signaling pathways.
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Growth factors are attractive therapeutic targets for the treatment of fibroids.