Interplay between TDP-43 and docosahexaenoic acid-related processes in amyotrophic lateral sclerosis
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- 作者：Daniel Cacabelosa ; 1 ; dcacabelos@mex.udl.cat" class="auth_mail" title="E-mail the corresponding author ; Victò ; ria Ayalaa ; 1 ; victoria.ayala@mex.udl.cat" class="auth_mail" title="E-mail the corresponding author ; Ana Belé ; n Granado-Serranoa ; 1 ; anabgs@mex.udl.cat" class="auth_mail" title="E-mail the corresponding author ; Mariona Jové ; a ; 1 ; mariona.jove@udl.cat" class="auth_mail" title="E-mail the corresponding author ; Pascual Torresa ; pascual.tc92@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Jordi Boadaa ; jboada@mex.udl.cat" class="auth_mail" title="E-mail the corresponding author ; Rosanna Cabré ; a ; rosanna.cabre@mex.udl.cat" class="auth_mail" title="E-mail the corresponding author ; Omar Ramí ; rez-Nú ; ñ ; eza ; omar.ramirez78@mex.udl.cat" class="auth_mail" title="E-mail the corresponding author ; Hugo Gonzaloa ; hugonzalo@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Aranzazu Soler-Canterob ; asocan@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; José ; Carlos Enrique Serranoa ; jceserrano@mex.udl.cat" class="auth_mail" title="E-mail the corresponding author ; Maria Josep Bellmunta ; mjosep.bellmunt@cmb.udl.cat" class="auth_mail" title="E-mail the corresponding author ; Marí ; a Paz Romerob ; maripaz@tecal.udl.cat" class="auth_mail" title="E-mail the corresponding author ; Marí ; a José ; Motilvab ; motilva@tecal.udl.cat" class="auth_mail" title="E-mail the corresponding author ; Takashi Nonakac ; nonaka-tk@igakuken.or.jp" class="auth_mail" title="E-mail the corresponding author ; Masato Hasegawab ; hasegawa-ms@igakuken.or.jp" class="auth_mail" title="E-mail the corresponding author ; Isidre Ferrerd ; e ; 8082ifa@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Reinald Pamplonaa ; reinald.pamplona@mex.udl.cat" class="auth_mail" title="E-mail the corresponding author ; Manuel Portero-Otí ; na ; manuel.portero@mex.udl.cat" class="auth_mail" title="E-mail the corresponding author
- 关键词：Motor neuron ; Lipidomic ; Oxidative stress ; TDP-43 ; Polyunsaturated fatty acids ; Mitochondria
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：88
- 期：Complete
- 页码：148-160
- 全文大小：2487 K
文摘
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Specific enzymes for DHA synthesis are altered in ALS.
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ALS is associated with changes in DHA-dependent synaptic proteins drebrin and syntaxin
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Chronic excitotoxicity changes nervous tissue lipidome profile compatible with increased DHA amount
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DHA synthesis is upregulated by oxidative stress at short term in cell culture
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Drebrin is depleted after TDP-43 aggregation and oxidative stress