Polycyclic compounds by sunlight exposure of the drug rosuvastatin in water
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- 作者：Anna Astarita ; Marina DellaGreca ; Maria Rosaria Iesce ; Sara Montanaro ; Lucio Previtera ; Fabio Temussi
- 关键词：Rosuvastatin ; Dihydrobenzoquinazolines ; Benzoquinazolines ; Photocyclization ; Photoxidation
- 刊名：Journal of Photochemistry and Photobiology A: Chemistry
- 出版年：2007
- 出版时间：15 April 2007
- 年：2007
- 卷：187
- 期：2-3
- 页码：263-268
- 全文大小：253 K
文摘
Irradiation of rosuvastatin in water by sunlight or UV lamp (Pyrex) affords cyclic compounds. The main photo-induced reaction is cyclization of the drug to give diastereomeric dihydrobenzoquinazolines. Products derived from side-chain loss were also isolated in the irradiation mixture, and characterized as dihydrobenzoquinazoline and benzoquinazoline derivatives by spectroscopic means. Photoproducts structure elucidation and mechanistic hypothesis are reported.