Dextromethorphan interactions with histaminergic and serotonergic treatments to reduce nicotine self-administration in rats
详细信息 查看全文
- 作者：Scott A. Briggs ; Brandon J. Hall ; Corinne Wells ; Susan Slade ; Paul Jaskowski ; Margaret Morrison ; Amir H. Rezvani ; Jed E. Rose ; Edward D. Levin ; edlevin@duke.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Dextromethorphan ; Histamine H1 receptors ; Pyrilamine ; Serotonin 5HT2C receptors ; Lorcaserin ; Nicotine self-administration
- 刊名：Pharmacology Biochemistry and Behavior
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：142
- 期：Complete
- 页码：1-7
- 全文大小：881 K
文摘
- •
Dextromethorphan decreased nicotine self-administration with the lowest effective dose of 3-mg/kg.
- •
Dextromethorphan combined with pyrilamine lowered nicotine self-administration relative to either alone.
- •
Dextromethorphan also has mutually augmenting effects with lorcaserin.
- •
Combination therapy may be more effective smoking cessation treatments than monotherapy.