Amitriptyline and carbamazepine utilize voltage-gated ion channel suppression to impair excitability of sensory dorsal horn neurons in thin tissue slice: An in vitro study
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- 作者：Matthias Wolffa ; Patrick Czorlichb ; Chandran Nagarajc ; Rose Schnö ; bel-Ehehalta ; Yingji Lid ; Grazyna Kwapiszewskac ; e ; Horst Olschewskid ; Stefan Heschle ; Andrea Olschewskic ; e ; andrea.olschewski@medunigraz.at" class="auth_mail" title="E-mail the corresponding author
- 关键词：Lamina I&ndash ; III ; Spinal cord ; Action potential ; Sensory neurons ; Antidepressants ; Firing pattern
- 刊名：Neuroscience Research
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：109
- 期：Complete
- 页码：16-27
- 全文大小：3445 K
文摘
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Distribution of voltage-gated Na+ and K+ channels in lamina I–III is provided.
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Effect of drugs used for the treatment of neuropathic pain is investigated.
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Mode of action of drugs in the central nervous system is proposed.
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The antinociceptive effects rely on the firing rate reduction of tonically-firing neurons.
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Amitriptyline and carbamazepine reduces the firing rate of adapting-firing neurones.