Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection
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- 作者：Mark R. Cronan1 ; Rebecca W. Beerman1 ; Allison F. Rosenberg1 ; Joseph W. Saelens1 ; Matthew G. Johnson2 ; 3 ; Stefan H. Oehlers1 ; Dana M. Sisk1 ; Kristen L. Jurcic Smith1 ; 3 ; Neil A. Medvitz4 ; Sara E. Miller4 ; Le A. Trinh6 ; Scott E. Fraser6 ; John F. Madden4 ; Joanne Turner7 ; 8 ; Jason E. Stout2 ; 3 ; Sunhee Lee1 ; 3 ; David M. Tobin1 ; 5 ; 9 ; david.tobin@duke.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Immunity
- 出版年：2016
- 出版时间：18 October 2016
- 年：2016
- 卷：45
- 期：4
- 页码：861-876
- 全文大小：8960 K
文摘
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Macrophages mobilize classical epithelial modules during granuloma formation
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Macrophage reprogramming shares features of mesenchymal-epithelial transitions
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Inhibition of macrophage epithelialization leads to disordered granulomas
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Granuloma disruption increases immune access and promotes host survival