Preemptive Bone Marrow Transplantation and Event-Free Survival in Fanconi Anemia
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- 作者：Nicholas E. Khan1 ; Philip S. Rosenberg2 ; Blanche P. Alter1 ; alterb@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：Preemptive transplantation ; Fanconi anemia ; Markov model ; Decision analysis
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：22
- 期：10
- 页码：1888-1892
- 全文大小：1053 K
文摘
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Preemptive bone marrow transplantation would prevent leukemia in patients with Fanconi anemia
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A transplantation incurs risks of transplantation-related mortality and solid tumors
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A mathematical model (Markov) estimated the risks and benefits of transplantation
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Preemptive bone marrow transplantation has more benefit for younger patients
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This model may be useful for shared decision-making between families and physicians