Memory and hippocampal architecture following short-term midazolam in western diet-treated rats
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- 作者：Dorothea S. Rosenbergera ; 1 ; dorothea.rosenberger@hsc.utah.edu" class="auth_mail" title="E-mail the corresponding author ; Maria F. Falangolab ; c ; d ; 1 ; Auré ; lie Ledreuxd ; Xingju Nieb ; c ; Wendy M. Suhree ; Heather A. Bogerd ; Ann-Charlotte Granholmd ; f
- 关键词：Midazolam ; Diffusional kurtosis imaging ; Western diet ; Spatial memory
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：16 May 2016
- 年：2016
- 卷：621
- 期：Complete
- 页码：68-74
- 全文大小：1043 K
文摘
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Effects of short-term midazolam exposure in middle-aged rats fed a “Western diet” or control diet were investigated.
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Short-term midazolam treatment gave rise to reduced learning and memory function in middle-aged rats.
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dMRI can be used for assessment of pharmacologically induced changes in hippocampal cytoarchitecture in rats.
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Midazolam effects on spatial memory may be stronger in those individuals with metabolic syndrome or long-term intake of a Western diet.