Radiogenomics: A systems biology approach to understanding genetic risk factors for radiotherapy toxicity?
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- 作者：Carsten Herskinda ; carsten.herskind@medma.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Christopher J. Talbotb ; Sarah L. Kernsc ; d ; Marlon R. Veldwijka ; Barry S. Rosensteinc ; e ; f ; Catharine M.L. Westg
- 关键词：Radiotherapy ; Normal-tissue reaction ; Predictive tests ; Single-nucleotide polymorphisms ; Genome-wide association studies ; Gene expression microarrays
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：382
- 期：1
- 页码：95-109
- 全文大小：682 K
文摘
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Different pathways are involved in normal-tissue reaction after radiotherapy.
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Combining different ‘omics’ techniques may identify critical pathways.
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Functional assays may identify patient subgroups with different mechanisms.
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A systems biology approach promises synergy from ‘omics’ and functional assays.