Protective role of klotho protein on epithelial cells upon co-culture with activated or senescent monocytes

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• 作者：Jennifer Mytych^a ; ^b ; ^{jennifermytych@gmail.com} ; Izabela Wos^a ; ^b ; Przemyslaw Solek^a ; ^b ; Marek Koziorowski^a ; ^b
• 关键词：Klotho ; Monocytes-epithelial cells interactions ; Stress ; DNA damage
• 刊名：Experimental Cell Research
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：350
• 期：2
• 页码：358-367
• 全文大小：1642 K
• 卷排序：350

文摘

Activated and senescent THP-1 monocytes induced cyto- and genotoxicity in HeLa cells. Altered monocytes provoked oxidative and nitrosative stress-induced DNA damage. DNA damage activated DDR pathways and lead to premature senescence and apoptosis. Klotho reduced ROS/RNS-mediated toxicity through insulin/IGF-IR pathway inhibition. Klotho protects HeLa cells from cyto- and genotoxicity induced by altered monocytes.