Significant cognitive improvement with cholinesterase inhibition in AD with cerebral amyloid angiopathy
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- 作者：Ross W. Paterson ; 1 ; r.paterson@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author ; rosspaterson@doctors.org.uk" class="auth_mail" title="E-mail the corresponding author ; Zeinab Abdi1 ; z.abdi@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Amanda Haines ; Jonathan M. Schott ; j.schott@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alzheimer&rsquo ; s disease ; Cerebral amyloid angiopathy ; Microhaemorrhage ; Stroke ; Amyloid spells ; Leukoaraiosis ; Acetyl-cholinesterase inhibitor ; Boston criteria
- 刊名：Clinical Neurology and Neurosurgery
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：144
- 期：Complete
- 页码：64-66
- 全文大小：521 K
文摘
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CAA pathology frequently accompanies AD pathology.
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CAA and AD pathology are likely to be mechanistically linked.
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Individuals with AD pathology alone; typical improvement ∼2 MMSE points with AchEI.
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Striking cognitive improvement in 3 people with CAA & AD treated with AchEI.