Distinct membrane properties are differentially influenced by cardiolipin content and acyl chain composition in biomimetic membranes

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• 作者：Edward Ross Pennington^a ; ^b ; Amy Fix^a ; E. Madison Sullivan^a ; ^b ; David A. Brown^c ; Anthony Kennedy^d ; Saame Raza Shaikh^a ; ^b ; ^{shaikhsa@ecu.edu}
• 关键词：Cardiolipin ; Pressure-area isotherms ; Docosahexaenoic acid ; Monolayers ; Mitochondria
• 刊名：Biochimica et Biophysica Acta (BBA) - Biomembranes
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1859
• 期：2
• 页码：257-267
• 全文大小：1323 K
• 卷排序：1859

文摘

In several diseases, cardiolipin (CL) content is lowered and acyl chains remodeled. CL content has a strong impact on physical properties of biomimetic membranes. Remodeling of (18:2)4CL to (14:0)4CL has a strong influence on membrane properties. (18:2)4CL, (18:1)4CL, and (22:6)4CL behave similarly in complex monolayers. CL content and acyl chain composition differentially target membrane organization.