Cellular expression of the cytolytic factor in earthworms Eisenia foetida
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- 作者：Bilej ; Martin ; Rossmann ; Pavel ; &Scaron ; inkora ; Marek ; Hanu&scaron ; ová ; Radka ; Beschin ; Alain ; et. al.
- 关键词：Eisenia foetida ; Coelomic fluid ; Coelomic cytolytic factor 1 (CCF-1) ; Lipopolysaccharide ; TNF ; Coelomocytes ; Chloragogenous tissue
- 刊名：Immunology Letters
- 出版年：1998
- 出版时间：January, 1998
- 年：1998
- 卷：60
- 期：1
- 页码：23-29
- 全文大小：766 K
文摘
Coelomic fluid of earthworms contains a 42 kDa protein designated CCF-1 (coelomic cytolytic factor 1), which accounts for approximately 40 % of cytolytic activity of the entire coelomic fluid. CCF-1 was documented to be present on cells of the mesenchymal lining of the coelomic cavity as well as on free coelomocytes. Both cellular and humoral levels of CCF-1 were significantly increased after parenteral injection of endotoxin. Moreover, CCF-1 seems to be involved in cell mediated cytotoxicity, because cytotoxic activity is blocked in the presence of anti-CCF-1 monoclonal antibody (mAb).