Detailed analysis of BALB/c mice challenged with wild type rotavirus EDIM provide an alternative for infection model of rotavirus

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• 作者：Jialiang Du^a ; ¹ ; Zhiling Lan^a ; ^b ; ¹ ; Yueyue Liu^a ; Yan Liu^a ; Yanchao Li^a ; ^c ; Xiangming Li^b ; Tai Guo^a ; ^{guotai@nifdc.org.cn}
• 关键词：Rotavirus ; Mouse ; EDIM ; Infection ; Animal model
• 刊名：Virus Research
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：228
• 期：Complete
• 页码：134-140
• 全文大小：1703 K
• 卷排序：228

文摘

The optimal age of mouse sensitive to rotavirus infection thus far has not been unified. We elucidated clinical symptoms, immune responses and pathological changes of mice in different ages after challenged by EDIM. Diarrhea illness, mobility, bodyweight were recorded, viral shedding and immune responses were detected. Small intestine tissue was evaluated for virus distribution and pathological changes. Two-week-old mice were more sensitive to EDIM infection and initiated more effective immune response, compared to others.