Divergent Expression and Metabolic Functions of Human Glucuronosyltransferases through Alternative Splicing
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- 作者：Michè ; le Rouleau1 ; 2 ; Alan Tourancheau1 ; 2 ; Camille Girard-Bock1 ; 2 ; Lyne Villeneuve1 ; 2 ; Jonathan Vaucher3 ; Anne-Marie Duperré ; 1 ; 2 ; Yannick Audet-Delage1 ; 2 ; Isabelle Gilbert1 ; 2 ; Ion Popa3 ; Arnaud Droit3 ; Chantal Guillemette1 ; 2 ; 4 ; chantal.guillemette@crchudequebec.ulaval.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：Glucuronosyltransferase (UGT) ; glucuronidation ; drug metabolism ; cell metabolism ; RNA sequencing ; alternative splicing ; transcriptome
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：27 September 2016
- 年：2016
- 卷：17
- 期：1
- 页码：114-124
- 全文大小：3471 K
文摘
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Alternative UGTs quantitatively represent 20%–60% of canonical transcripts
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20% of these UGTs acquire sequences predicted to give distinct structural features
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Alternative UGTs with in-frame sequences modify cell detoxification activity
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These UGTs are linked to changes in metabolism and cellular phenotypes