Angiogenic sprouting from the aortic vascular wall is impaired in the BB rat model of autoimmune diabetes

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• 作者：Geanina Onuta ; Peter E. Westerweel ; André ; Z ; voort ; Manon van Riezen ; Jan Rozing ; Jan-Luuk Hillebr ; s ; Marianne C. Verhaar
• 关键词：Angiogenesis ; Diabetes ; Endothelial cell sprouting ; Angiogenesis model
• 刊名：Microvascular Research
• 出版年：2008
• 出版时间：April 2008
• 年：2008
• 卷：75
• 期：3
• 页码：420-425
• 全文大小：2236 K

文摘

Diabetes is associated with impaired neovascularization leading to reduced revascularization of ischemic tissue and impaired wound healing. Endothelial progenitor cells in diabetes were previously shown to be numerically reduced and functionally impaired. We hypothesize that diabetes also has a long-term effect on angiogenic cells residing in the vessel wall. To test this hypothesis, angiogenic sprout formation from ex vitro cultured aortic rings isolated from diabetic and non-diabetic BioBreeding (BB) rats was assessed.