Lack of the P2X₇ receptor protects against AMD-like defects and microparticle accumulation in a chronic oxidative stress-induced mouse model of AMD

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• 作者：Kyle A. Carver^a ; C.M. Lin^a ; Catherine Bowes Rickman^b ; ^c ; Dongli Yang^a ; ^{dlyang@umich.edu}
• 关键词：P2X7 receptor ; Sod1 ; AMD ; Retinal pigmented epithelium (RPE) ; Oxidative stress ; Microparticle (MP)
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：482
• 期：1
• 页码：81-86
• 全文大小：1640 K
• 卷排序：482

文摘

Lack of P2X7 receptor blocks RPE and retina oxidative stress in Sod1 knockout mice. Lack of P2X7 receptor protects against AMD-like defects in Sod1 knockout mice. Lack of P2X7 receptor prevents microparticle accumulation in Sod1 knockout mice. Targeting P2X7 receptor could potentially lead to novel therapies for AMD.