Evidence of anhedonia and differential reward processing in prefrontal cortex among post-withdrawal patients with prescription opiate dependence
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- 作者：A.S. Huhna ; R.E. Meyera ; J.D. Harrisa ; H. Ayazb ; E. Denekec ; D.M. Stankoskia ; S.C. Buncea ; b ; sbunce@hmc.psu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：(PODP) ; Prescription opiate dependent patients ; (AMSR) ; ffect-modulated startle response ; (PFC) ; prefrontal cortex ; (RPFC) ; rostral PFC ; (VLPFC) ; ventrolateral PFC ; (fNIRS) ; functional near-infrared spectroscopy
- 刊名：Brain Research Bulletin
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：123
- 期：Complete
- 页码：102-109
- 全文大小：1715 K
文摘
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Markers of anhedonia were assessed in recently withdrawn opiate dependent patients.
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Patients reported reduced positive affect on Snaith–Hamilton Pleasure Scale (LowPA).
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Affect-modulated startle to pleasant images was blunted in patients reporting LowPA.
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Patients had reduced activation of prefrontal cortex to food/social reward cues.
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Multimodal approach, translational neuroimaging suggest anhedonia in early recovery.