A Novel Bullet Hits the Proteasome

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• 作者：Alexei聽F. Kisselev
• 刊名：Cancer Cell
• 出版年：9 December, 2013
• 年：2013
• 卷：24
• 期：6
• 页码：691-693
• 全文大小：411 K

文摘

An elegant paper by Anchoori and colleagues in this issue of Cancer Cell describes an irreversible inhibitor of Rpn13, one of the ubiquitin receptors on the 26S proteasome that is nonessential for proteasome function in most normal tissues, but is overexpressed in many solid tumors.