Antibiotic resistance determinants of multidrug-resistant Acinetobacter baumannii clinical isolates in Algeria

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• 作者：Sofiane Bakour ; Abdelaziz Touati ; Farida Sahli ; Abdennour Ait Ameur ; Djamila Haouchine ; Jean-Marc Rolain
• 关键词：Multidrug resistant bacteria ; Acinetobacter baumannii ; Aminoglycoside-modifying enzymes ; Rifampin resistance
• 刊名：Diagnostic Microbiology and Infectious Disease
• 出版年：2013
• 出版时间：August, 2013
• 年：2013
• 卷：76
• 期：4
• 页码：529-531
• 全文大小：290 K

文摘

Antibiotic susceptibility testing was performed on 71 Acinetobacter baumannii clinical isolates, and presence of antibiotic resistance genes was screened for by PCR amplification and sequencing. Resistance rates were very high for aminoglycosides (22-80 % ), fluoroquinolones (>90 % ), and cephalosporins (>90 % ) but remained low for rifampin (2.8 % ) or null for colistin. Antibiotic resistance encoding genes detected were as follows: bla_TEM-128 gene (74.6 % ), aph(3¡ä)-VI (50.7 % ), aadA (63.4 % ), ant(2¡å)-I (14.1 % ), aac(3)-Ia (91.1 % ), aac(6¡ä)-Ib (4.2 % ), mutation Ser83Leu in gyrA (94.4 % ), double mutations Ser83Leu and Ser80Leu (or Ser84Leu) in gyrA and parC (69.0 % ), and mutation I581N in RRDR of the rpoB gene.