Interaction between subclinical doses of the Parkinson’s disease associated gene, α-synuclein, and the pesticide, rotenone, precipitates motor dysfunction and nigrostriatal neurodegeneration in rats
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- 作者：Carol Naughtona ; b ; c ; Daniel O&rsquo ; Tooleb ; Deniz Kirikd ; Eilí ; s Dowd ; Dr.a ; b ; c ; eilis.dowd@nuigalway.ie" class="auth_mail" title="E-mail the corresponding author
- 关键词：Parkinson&rsquo ; s disease ; Animal model ; Gene-environment ; α-synuclein ; Rotenone ; AAV
- 刊名：Behavioural Brain Research
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：316
- 期：Complete
- 页码：160-168
- 全文大小：1939 K
文摘
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Various risk factors may interact to precipitate presymptomatic Parkinson’s disease.
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We investigated the interaction between α-synuclein and the pesticide, rotenone.
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Dual exposure to α-synuclein and rotenone precipitated Parkinsonism in rats.
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Rats exposed to both factors had profound motor dysfunction and neurodegeneration.
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This highlights the importance of these interactions in Parkinson’s disease.