Disordered APP metabolism and neurovasculature in trauma and aging: Combined risks for chronic neurodegenerative disorders

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• 作者：Milos D. Ikonomovic^a ; ^b ; ^c ; ^{ikonomovicmd@upmc.edu} ; Zhiping Mi^a ; ^b ; Eric E. Abrahamson^a ; ^b
• 关键词：Aging ; Alzheimer&rsquo ; s disease ; Amyloid-beta ; Brain trauma ; Neurodegeneration ; Neurovascular unit
• 刊名：Ageing Research Reviews
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：34
• 期：Complete
• 页码：51-63
• 全文大小：2710 K
• 卷排序：34

文摘

Traumatic brain injury (TBI), advanced age, and cerebral vascular disease are major risk factors for Alzheimer’s disease (AD). Amyloid-β contributes to chronic neuronal and synaptic loss after TBI. These effects are potentiated by aging and cerebral vascular dysfunction. Severe and repetitive mild TBI produce complex polypathologies, with different contributions of Aβ and tau pathology at different times after TBI.