Ipsilateral hippocampal CA1 LTP was increased at 1 week following 3 × CHI.
3 × CHI mice were impaired in hippocampal-dependent behavioral tasks.
Action potential amplitude was increased with rise & decay times decreased.
Frequencies of spontaneous excitatory and inhibitory currents were abnormal.
Results are consistent with 3 × CHI triggering remodeling of hippocampal circuitry.