SMIFH2-mediated mDia formin functional inhibition potentiates chemotherapeutic targeting of human ovarian cancer spheroids
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- 作者：Megan A. Ziske1 ; Krista M. Pettee1 ; MaNada Khaing ; Kaitlin Rubinic ; Kathryn M. Eisenmann ; kathryn.eisenmann@utoledo.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cytoskeleton ; Ovarian cancer ; Formin ; Spheroid ; mDia ; SMIFH2
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：25 March 2016
- 年：2016
- 卷：472
- 期：1
- 页码：33-39
- 全文大小：1243 K
文摘
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Spheroids are clinically relevant structures underlying EOC metastasis.
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mDia formins are cytoskeletal effectors regulating EOC spheroid integrity.
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Combined therapy of mDia functional inhibition with chemotherapeutics is tested.
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Taxol with mDia inhibition combined to effectively block spheroid viability.