Incidence and Predictors of Cardiomyocyte Injury in Elective Coronary Angiography

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• 作者：Philipp Kreutzinger ; MD^a ; Karin Wildi ; MD^a ; ^b ; Raphael Twerenbold ; MD^a ; Maria Rubini Gimenez ; MD^a ; ^b ; Tobias Reichlin ; MD^a ; Cedric Jaeger ; MD^a ; ^b ; Petra Hillinger ; MD^a ; ^b ; Jasper Boeddinghaus ; MD^a ; Thomas Nestelberger ; MD^a ; Christian Puelacher ; MD^a ; Fabio Stallone ; MD^a ; ^b ; Katharina Rentsch ; PhD^c ; Stefan Osswald ; MD^a ; Raban Jeger ; MD^a ; Christoph Kaiser ; MD^a ; Christian Mueller ; MD^a ; ^{Christian.Mueller@usb.ch" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Coronary angiography ; Myocardial infarction ; Myocardial injury ; Predictors of cardiomyocyte injury
• 刊名：The American Journal of Medicine
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：129
• 期：5
• 页码：537.e1-537.e8
• 全文大小：425 K

文摘

Coronary angiography is considered to be a safe tool for the evaluation of coronary artery disease and performed in approximately 12 million patients each year worldwide. The aim of our study was to investigate the frequency and predictors of cardiomyocyte injury in patients undergoing elective coronary angiography.

absSec_2">Methods

abspara0015">A total of 749 consecutive patients who were scheduled to undergo elective coronary angiography were prospectively analyzed. High-sensitivity cardiac troponin T concentrations were measured both before and after elective coronary angiography (without intervention). Acute cardiomyocyte injury was predefined as an absolute increase in high-sensitivity cardiac troponin T of at least 7 ng/L (if also fulfilling a relative change of >20%).

absSec_3">Results

abspara0020">Acute cardiomyocyte injury was observed in 101 patients (13.5%, 95% confidence interval [CI], 11.1-16.2). It was independently associated with aortic valve stenosis (odds ratio [OR], 5.4; 95% CI, 3.0-9.8; P <.001), age (OR, 1.05; 95% CI, 1.02-1.08; P <.001), female sex (OR, 3.5; 95% CI, 1.8-6.8; P <.001), contrast volume (OR, 1.006; 95% CI, 1.001-1.012; P = .019 per 10 mL of contrast volume), documented cardiomyopathy (OR, 2.5; 95% CI, 1.0-6.0; P = .045), and mitral regurgitation (OR, 2.3; CI, 1.0-4.9; P = .033). In contrast, operator experience and extent of coronary artery disease were not found to be associated with acute cardiomyocyte injury.

absSec_4">Conclusions

abspara0025">Cardiomyocyte injury accompanies elective coronary angiography in 1 of 8 patients. Sex, age, contrast agent volume, and ventricular disease, rather than the extent of coronary artery disease, independently predict cardiomyocyte injury. Further research aiming to reduce the incidence of cardiomyocyte injury seems warranted.