Synergistic catalytic activity of RuCl3 and OsO4 on the selective oxidation of pregabalin drug molecule: Exploration of scope, reaction mechanism and kinetic modeling
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- 作者：S. Dakshayani ; Puttaswamy ; pswamy_chem@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：(RuCl3 ; + ; OsO4) catalysis ; Pregabalin ; Chloramine-T ; Oxidation-kinetics
- 刊名：Applied Catalysis A: General
- 出版年：2016
- 出版时间：5 March 2016
- 年：2016
- 卷：513
- 期：Complete
- 页码：116-126
- 全文大小：831 K
文摘
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The kinetic and mechanistic picture of oxidation of pregabalin with alkaline chloramine-T have been clarified.
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The catalytic efficiency of the catalysts used follows the order: (RuCl3 + OsO4) > OsO4 > RuCl3.
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The most noteworthy is the significant synergistic effect of 71-fold in case of (RuCl3 + OsO4) catalyst.