Human Naive Pluripotent Stem Cells Model X Chromosome Dampening and X Inactivation

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• 作者：Anna Sahakyan¹ ; ² ; Rachel Kim³ ; Constantinos Chronis¹ ; Shan Sabri¹ ; ³ ; ⁶ ; Giancarlo Bonora¹ ; ⁶ ; Thorold W. Theunissen⁷ ; Edward Kuoy¹ ; Justin Langerman¹ ; Amander T. Clark² ; ³ ; ⁴ ; ⁵ ; Rudolf Jaenisch⁷ ; ⁸ ; Kathrin Plath¹ ; ² ; ³ ; ⁴ ; ⁶ ; ⁹ ; ^{kplath@mednet.ucla.edu}
• 关键词：XIST ; X chromosome ; X chromosome inactivation ; X chromosome dampening ; naive pluripotency ; embryonic stem cells ; pluripotent stem cells ; human stem cells ; lncRNA ; human development
• 刊名：Cell Stem Cell
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：20
• 期：1
• 页码：87-101
• 全文大小：5708 K
• 卷排序：20

文摘

Naive female hPSCs have two active X chromosomes (XaXa) and express XIST RNA Differentiation of naive hPSCs prompts X inactivation via a state without XIST Some X chromosome features of the embryo are not captured by naive hPSCs The naive state erases epigenetic abnormalities of the Xi seen in primed hPSCs