Glycidamide genotoxicity modulated by Caspases genes polymorphisms
详细信息 查看全文
- 作者：Joã ; o Pereira de Limaa ; Susana N. Silvaa ; José ; Rueffa ; Marta Pingarilhoa ; b ; martapingarilho@ihmt.unl.pt" class="auth_mail" title="E-mail the corresponding author ; jose.rueff@nms.unl.pt" class="auth_mail" title="E-mail the corresponding author
- 关键词：Acrylamide ; Glycidamide ; Apoptosis ; Caspases genes polymorphisms ; DNA damage ; Cancer susceptibility
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：34
- 期：Complete
- 页码：123-127
- 全文大小：244 K
文摘
- •
CASP8 rs1035142 modify yields of SCEs by glycidamide.
- •
CASP10 rs13006529 and SNP–SNP interactions of CASP8 and CASP10 modify % tail DNA.
- •
Variants of CASP7, CASP9, LTA and TNFRSF1B had no effect on glycidamide genotoxicity.
- •
The data is a proof of concept that apoptotic effectors influence the genotoxicity.