Facilitation of glutamatergic synaptic transmission in hippocampal CA1 area of rats with traumatic brain injury

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• 作者：Ruifeng Cao ; Hiroshi Hasuo ; Satomi Ooba ; Takashi Akasu and Xiang Zhang
• 关键词：Traumatic brain injury ; Hippocampal CA1 ; Intracellular recording ; Excitability ; Synaptic transmission ; Glutamate release
• 刊名：Neuroscience Letters
• 出版年：2006
• 出版时间：19 June 2006
• 年：2006
• 卷：401
• 期：1-2
• 页码：136-141
• 全文大小：157 K

文摘

We investigated the effects of traumatic brain injury (TBI) on the glutamatergic synaptic transmission in the hippocampal CA1 area. A moderate impact (3.8–4.8 atm) was applied onto the left parietal cerebral cortex by a fluid percussion injury (FPI) device. Conventional intracellular recordings were made from hippocampal CA1 pyramidal neurons in vitro. Electrophysiological properties of these neurons were compared between three groups (control, FPI-ipsilateral, and FPI-contralateral). The excitability of postsynaptic membrane of CA1 pyramidal neurons was not altered by the moderate FPI; however, the evoked glutamatergic excitatory synaptic transmission in the pyramidal neurons of post-FPI-CA1 was enhanced. Paired-pulse facilitation (PPF) was significantly suppressed in both the FPI-ipsilateral and FPI-contralateral groups and the frequencies of mEPSPs in neurons from the bilateral FPI groups were greater than the frequency in the control group. These results suggest that the glutamatergic synaptic transmission in the hipppocampal CA1 area is facilitated through presynaptic mechanisms after TBI.