Curcumin attenuates inflammatory responses by suppressing TLR4-mediated NF-魏B signaling pathway in lipopolysaccharide-induced mastitis in mice
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- 作者：Yunhe Fu ; Ruifeng Gao ; Yongguo Cao ; Mengyao Guo ; Zhengkai Wei ; Ershun Zhou ; Yimeng Li ; Minjun Yao ; Zhengtao Yang ; Naisheng Zhang ; yangzhengtao01@sina.com" class="auth_mail
- 关键词：Curcumin ; Mastitis ; Myeloperoxidase ; Nuclear factor-kappa B (NF-魏B) ; TLR4
- 刊名：International Immunopharmacology
- 出版年：May 2014
- 年：2014
- 卷：20
- 期：1
- 页码：54-58
- 全文大小：1335 K
文摘
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Curcumin attenuated histopathologic changes and myeloperoxidase activity after administration of LPS in mice.
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Curcumin decreased the release of TNF-伪, IL-6 and IL-1尾 in a dose-dependent manner in LPS-induced mastitis in mice.
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Curcumin exerted anti-inflammatory effect by inhibiting TLR4-mediated NF-魏B signaling pathways in LPS-induced mouse mastitis.