Defining a novel leptin-melanocortin-kisspeptin pathway involved in the metabolic control of puberty
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- 作者：Maria Manfredi-Lozano1 ; 2 ; 3 ; 7 ; Juan Roa1 ; 2 ; 3 ; 4 ; 7 ; roarivas@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Francisco Ruiz-Pino1 ; 2 ; 3 ; 4 ; Richard Piet6 ; David Garcia-Galiano1 ; 2 ; Rafael Pineda1 ; Aurora Zamora1 ; 2 ; Silvia Leon1 ; 2 ; Miguel A. Sanchez-Garrido1 ; 2 ; 4 ; Antonio Romero-Ruiz1 ; 2 ; Carlos Dieguez5 ; Maria Jesus Vazquez1 ; 2 ; 3 ; 4 ; Allan E. Herbison6 ; Leonor Pinilla1 ; 2 ; 3 ; 4 ; Manuel Tena-Sempere1 ; 2 ; 3 ; 4 ; fi1tesem@uco.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：α-MSH ; Kisspeptin ; Leptin ; Metabolism ; DREADDs ; Puberty
- 刊名：Molecular Metabolism
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：5
- 期：10
- 页码：844-857
- 全文大小：1972 K
文摘
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Puberty is highly sensitive to metabolic modulation and disturbed by child obesity.
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Altered puberty is linked to adverse metabolic health outcomes via unclear mechanisms.
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The POMC product, α-MSH, transmit leptin-mediated metabolic regulation of puberty.
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A novel α-MSH→kisspeptin→GnRH signaling pathway is involved in the control of puberty
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This pathway is important for the metabolic (and pharmacologic) control of puberty.