Surfactant effect on the physicochemical characteristics of γ-oryanol-containing solid lipid nanoparticles
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- 作者：Kullavadee Karn-orachaia ; Siwaporn Meejoo Smithb ; siwaporn.smi@mahidol.ac.th" class="auth_mail" title="E-mail the corresponding author ; Somsak Saesooc ; Alongkot Treethongc ; Satit Puttipipatkhachornd ; Sirapat Pratontepe ; Uracha Rungsardthong Ruktanonchaic ; uracha@nanotec.or.th" class="auth_mail" title="E-mail the corresponding author
- 关键词：Solid lipid nanoparticles ; Surfactant ; Drug delivery ; Nanocarrier ; γ-Oryzanol
- 刊名：Colloids and Surfaces A: Physicochemical and Engineering Aspects
- 出版年：2016
- 出版时间：5 January 2016
- 年：2016
- 卷：488
- 期：Complete
- 页码：118-128
- 全文大小：3168 K
文摘
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Cationic, anionic and non-ionic surfactants were explored on Compritol based SLNs.
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Properties of drug-loaded SLNs are influenced by the surfactant composition.
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Mixed surfactant-SLNs show superior stability due to enhanced drug incorporation.
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Mixed surfactant-SLNs show high cell internalization ability and low cytotoxicity.
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Charges, bulkiness of the non-ionic surfactant and ion-pairing effects play a role.