Platelet-derived growth factor regulates the proliferation and differentiation of human melanocytes in a differentiation-stage-specific manner
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- 作者：Tomohisa Hirobea ; thirobe@nirs.go.jp" class="auth_mail" title="E-mail the corresponding author ; Tatako Shibatab ; Rumiko Fujiwarab ; Kiyoshi Satob
- 关键词：Skin ; Proliferation ; Differentiation ; Melanocyte ; Dermis
- 刊名：Journal of Dermatological Science
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：83
- 期：3
- 页码：200-209
- 全文大小：2523 K
文摘
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It is not well defined whether dermis-derived factors regulate the proliferation and differentiation of human melanocytes.
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PDGF-BB stimulated the proliferation of cultured melanoblasts, but inhibited the proliferation of melanocytes.
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PDGF-BB promoted melanocyte differentiation through the stimulation of the expressions of tyrosinase and tyrosinase-related protein-1.
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PDGF-BB regulates the proliferation and differentiation of human melanocytes in a differentiation-stage-specific manner.