T-2 toxin induces the expression of porcine CYP3A22 via the upregulation of the transcription factor, NF-Y
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- 作者：Xin Liu1 ; Jikai Wen1 ; Ruohong Chen ; Tingting Zhang ; Jun Jiang ; Yiqun Deng ; yqdeng@scau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：CYP3A22 ; T-2 toxin ; Sp1 ; NF-Y ; Transcription regulation
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：1860
- 期：10
- 页码：2191-2201
- 全文大小：1085 K
文摘
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Two cis elements, a CCAAT box and GC box, in the proximal promoter activate the transcription of porcine CYP3A22.
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NF-Y and Sp1, which bind to the CCAAT box and GC box, contribute the basal/constitutive transcription of CYP3A22.
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The transactivation of CYP3A22 by T-2 toxin depends on the recruitment of NF-Y to the CCAAT box in the promoter.