Two cis elements, a CCAAT box and GC box, in the proximal promoter activate the transcription of porcine CYP3A22.
NF-Y and Sp1, which bind to the CCAAT box and GC box, contribute the basal/constitutive transcription of CYP3A22.
The transactivation of CYP3A22 by T-2 toxin depends on the recruitment of NF-Y to the CCAAT box in the promoter.