Management of complicated chronic anal fissures with high-dose circumferential chemodenervation (HDCC) of the internal anal sphincter
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- 作者：James Z. Whatleya ; Shou-jiang Tanga ; stang@umc.edu" class="auth_mail" title="E-mail the corresponding author ; Porter H. Glovera ; Eric D. Davisa ; Kellen T. Jexa ; Ruonan Wua ; Christopher J. Lahrb
- 关键词：High-dose circumferential chemodenervation ; Chronic anal fissure ; Injection ; Botulinum toxin ; Lateral internal sphincterotomy ; Healing rate
- 刊名：International Journal of Surgery
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：24
- 期：part_PA
- 页码：24-26
- 全文大小：217 K
文摘
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Botulinum toxin injection into the internal anal sphincter (IAS) is a second line therapy for anal fissures.
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High-dose circumferential chemodenervation (HDCC) of 100 IU is proposed.
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Of the 62 patients, the overall success rate was greater than 70% at 3 months follow-up.
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Combination therapy involving HDCC-IAS is a safe and effective method.