Elevated E2F7 expression predicts poor prognosis in human patients with gliomas
详细信息 查看全文
- 作者：WenWen Yina ; 1 ; Bo Wanga ; 1 ; MaoHua Dingb ; 1 ; Yan Huoa ; Hao Hua ; RuoNan Caia ; TingTing Zhoua ; ZaoHua Gaoa ; ZaoLing Wanga ; dyyywzl@126.com" class="auth_mail" title="E-mail the corresponding author ; DeZhi Chena ; chendezhixz@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：CDK1 ; E2F7 ; Glioma ; Prognosis ; Tumor grade
- 刊名：Journal of Clinical Neuroscience
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：33
- 期：Complete
- 页码：187-193
- 全文大小：1502 K
文摘
- •
We investigated the relationship between atypical E2F transcription factor, E2F7 and clinical prognosis of human glioma.
- •
Indeed, we demonstrated E2F7 predicts tumor progression and poor prognosis in glioma.
- •
We demonstrated that elevated E2F7 expression in glioma is proportional to expression of CDK1.
- •
Over-expression of CDK1 was found to promote oncogenesis and progression of human glioma.
- •
These results support a role for the E2F7 gene in glioma and uncover diagnostic and therapeutic expectations.