Disrupted anatomic networks in the 22q11.2 deletion syndrome

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• 作者：J. Eric Schmitt ; MD PhD^a ; ^b ; ^{eric.schmitt@stanfordalumni.org} ; James Yi ; MD PhD^a ; ^c ; Monica E. Calkins ; PhD^a ; Kosha Ruparel ; MS^a ; David R. Roalf ; PhD^a ; Amy Cassidy ; MS^a ; Margaret C. Souders ; PhD CRNP^d ; Theodore D. Satterthwaite ; MD MA^a ; Donna M. McDonald-McGinn ; MS CGC^d ; ^e ; Elaine H. Zackai ; MD^d ; ^e ; Ruben C. Gur ; PhD^a ; ^b ; Beverly S. Emanuel ; PhD^d ; ^e ; Raquel E. Gur ; MD PhD^a ; ^b
• 关键词：22q11DS ; cortical thickness ; morphometry ; network ; MRI ; schizophrenia
• 刊名：NeuroImage: Clinical
• 出版年：2016
• 出版时间：2016
• 年：2016
• 卷：12
• 期：Complete
• 页码：420-428
• 全文大小：1529 K
• 卷排序：12

文摘

Individuals with 22q11 deletions have a significantly increased risk of psychosis. There are statistically significant differences in anatomic network structure in 22q11DS compared to typically developing controls. Similar findings have been observed in idiopathic schizophrenia.