Direct S-difluoromethylation of thiols using the Ruppert-Prakash reagent
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- 作者：G.K. Surya Prakash ; gprakash@usc.edu" class="auth_mail" title="E-mail the corresponding author ; Sankarganesh Krishnamoorthy ; Sayan Kar ; George A. Olah
- 关键词：Ruppert&ndash ; Prakash reagent ; TMSCF3 ; Difluoromethylation ; Thiols ; Siladifluoromethylation ; Difluoromethyl thioethers ; Nucleophilic (arylsulfanyl)difluoromethylation ; RSCF2H ; RSCF2TMS
- 刊名：Journal of Fluorine Chemistry
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：180
- 期：Complete
- 页码：186-191
- 全文大小：636 K
文摘
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Direct S-difluoromethylation of aliphatic and aromatic thiols using TMSCF3.
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Selective S-difluoromethylation in presence of
OH, NH2 and CO2H functional groups.- •
One-pot nucleophilic (arylsulfanyl)difluoromethylation of PhCHO.
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Short reaction times and ambient temperatures.