Mild hypoxia preconditioning prevents impairment of passive avoidance learning and suppression of brain NGFI-A expression induced by severe hypoxia
详细信息 查看全文
- 作者：Rybnikova ; Elena ; Vataeva ; Ludmila ; Tyulkova ; Ekaterina ; Gluschenko ; Tatiana ; Otellin ; Vladimir ; et. al.
- 关键词：Brain ; Hypoxic damage and tolerance ; NGFI-A expression ; Passive avoidance
- 刊名：Behavioural Brain Research
- 出版年：2005
- 出版时间：May 7, 2005
- 年：2005
- 卷：160
- 期：1
- 页码：107-114
- 全文大小：386 K
文摘
The aim of this work was to study effects of mild preconditioning hypobaric hypoxia (380 Torr for 2 h, repeated 3 or 6 times spaced at 24 h) on brain NGFI-A immunoreactivity and passive avoidance (PA) behavior in rats exposed to severe hypoxia (160 Torr for 3 h). Severe hypobaric hypoxia produced extensive neuronal loss in hippocampal CA1, while the preceding hypoxic preconditioning had clear protective effect on neuronal viability of vulnerable hippocampal cells. Besides, the hypoxic preconditioning prevented impairment of acquisition and retention of PA caused by severe hypoxia. The six-trial hypobaric preconditioning was more effective in protection against PA learning deficits in severe hypoxia exposed rats than the three-trial preconditioning. The preconditioning up-regulated severe hypoxia-suppressed neocortical and hippocampal expression of NGFI-A, suggesting a possible role for NGFI-A in the neuroprotective mechanisms activated by hypoxic preconditioning.