Antidepressant-like effects of mild hypoxia preconditioning in the learned helplessness model in rats
详细信息 查看全文
- 作者：Elena Rybnikova ; Vera Mironova ; Svetlana Pivina ; Ekaterina Tulkova ; Natalia Ordyan ; Ludmila Vataeva ; Elena Vershinina ; Eugeny Abritalin ; Alex ; r Kolchev ; Natalia Nalivaeva ; et al.
- 关键词：Depression ; Learned helplessness model ; Hypoxic preconditioning ; Hypoxic/ischemic tolerance
- 刊名：Neuroscience Letters
- 出版年：2007
- 出版时间：7 May 2007
- 年：2007
- 卷：417
- 期：3
- 页码：234-239
- 全文大小：391 K
文摘
The effects of preconditioning using mild repetitive hypobaric hypoxia (360 Torr for 2 h each of 3 days) have been studied in the learned helplessness model of depression in rats. Male Wistar rats displayed persistent depressive symptoms (depressive-like behaviour in open field, increased anxiety levels in elevated plus maze, ahedonia, elevated plasma glucocorticoids and impaired dexamethasone test) following the exposure to unpredictable and inescapable footshock in the learned helplessness paradigm. Antidepressant treatment (ludiomil, 5 mg/kg i.p.) augmented the development of the depressive state. The hypoxic preconditioning had a clear antidepressive action returning the behavioural and hormonal parameters to the control values and was equally effective in terms of our study as the antidepressant. The findings suggest hypoxic preconditioning as an effective tool for the prophylaxis of post-stress affective pathologies in humans.