Inhibition of Sphingosine-1-phosphate receptors in ischemia reperfusion injured autoimmunity-prone mice

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• 作者：Jess Edison^a ; ¹ ; Sharon Frattalone^a ; ¹ ; Christopher Tracy^a ; ¹ ; Geoffrey E. Woodard^b ; Melissa Butts^a ; C.M. Moratz^c ; ^{Chantal.Moratz@usuhs.edu}
• 关键词：FTY720 ; Fingolimod ; PTX ; Pertussis toxin ; S1P ; Sphingosine-1-phosphate ; IR ; mesenteric ischemia reperfusion
• 刊名：Cellular Immunology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：311
• 期：Complete
• 页码：63-70
• 全文大小：1917 K
• 卷排序：311

文摘

B6.MRL/lpr display a chronic pro-inflammatory microenvironment at vascular barriers. Inhibition of S1P Receptor signaling is efficacious in attenuating injury in the B6.MRL/lpr strain. A shift from S1P1 to S1P2 usage by vascular endothelium is detected in the B6.MRL/lpr strain.